Thionyl Chloride → HCID 18672149, compound

HRID 1057758Notes

Reaction equation

HRID 1057758 reaction equation
[Cl:1][C:2]1[O:6][N:5]=[C:4]([C:7]([OH:9])=O)[CH:3]=1.O=S(Cl)[Cl:12]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[O:6][N:5]=[C:4]([C:7]([Cl:12])=[O:9])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 223114305-Chloro-1,2-oxazole-3-carboxylic acid

Product 1

HCID 18672149HCID 18672149, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To solution of 5-chloroisoxazole-3-carboxylic acid (Example 22, 0.253 g, 1.71 mmol, 2.0 equiv) in CHCl3 (21 mL) was added SOCl2 (9 mL). The reaction mixture was heated to reflux for 26 h. The volatiles were removed under reduced pressure to give crude 5-chloroisoxazole-3-carbonyl chloride.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 26 h
  3. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-8d79b400620d4a2685d983a02a345fb4
Source dataset
uspto-grants-2003_02
Patent number
US06514997B2

Reaction notes

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