Carvedilol → HCID 86758822, compound

HRID 1057765Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[CH3:31][S:32]([O-:35])(=[O:34])=[O:33]

Participants

Reactant 2

HCID 2585Carvedilol2×

HCID 6395Methanesulfonic Acid

Product 1

HCID 86758822HCID 86758822, compound

Procedure

Carvedilol was suspended in an aqueous solution of methanesulfonic acid, with the acid being present at a 1:1 molar ratio. The suspension is vortexed during the addition of carvedilol powder. After storage of the suspension for 6-15 hrs, the suspension is filtered and the solid residue is dried.

Workup

filtrationthe suspension is filtered
customthe solid residue is dried

Sources & evidence

ORD record: ord-34c8bbaf6c384803bd55ac0d22096087
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06515010B1

Reaction notes

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