反应详情

To a solution of methyl 2-(2-(t-butyldimethylsilyl-oxyethyl)-indole-5-acetate (400 mg; 1.15 mmol) in ca. 4 ml of THF was added a 1 M tetrabutylammonium fluoride in THF (1.2 mL; 1.05 eq) at 0° C. After 15 minutes, the reaction was allowed to warm to room temperature and stirred for an additional 3 hours. It was concentrated, diluted with water and extracted with ethyl acetate. The organic layer was washed with water, dried (Na2SO4), concentrated and chromatographed (silica gel, hexane:ethyl acetate 4:1) to yield 241 mg of the title compound as a colorless oil.

1. concentrationIt was concentrated
2. additiondiluted with water
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customchromatographed (silica gel, hexane:ethyl acetate 4:1)