反应详情

The phenol of Step B (141.4 g, 0.62 mole) was taken into 2 liters of ethyl acetate and the reaction vessel charged with 10% Pd/C catalyst (12 g). The reaction was stirred under H2 until the starting material was consumed. The reaction mixture was filtered through Celite and the cake washed with ethyl acetate (total volume ˜6 liters). The filtrate was concentrated to a dark oil which was taken into ether (1500 mL) and washed with 2N HCl (200 mL) sat'd. sodium bicarbonate and brine. The organic solution was dried over magnesium sulfate, filtered and concentrated to give a light brown oil. (125 g).

1. customwas consumed
2. filtrationThe reaction mixture was filtered through Celite
3. washthe cake washed with ethyl acetate (total volume ˜6 liters)
4. concentrationThe filtrate was concentrated to a dark oil which
5. washwashed with 2N HCl (200 mL)
6. dry with materialThe organic solution was dried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated
9. customto give a light brown oil