1,2-Dichlorobenzene → 4-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol

HRID 1057814Notes

Reaction equation

HRID 1057814 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)C=C.Cl[C:20]1[CH:25]=CC=C[C:21]=1Cl>>[F:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[C:10]([CH2:25][CH:20]=[CH2:21])[CH:9]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 72391,2-DichlorobenzeneHCID 186724764-(4-Fluorophenoxy)phenyl allyl ether

Product 1

HCID 186724734-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol

Procedure

4-(4-fluorophenoxy)phenyl allyl ether (4.00 g, 16.37 mmol) was taken up in 1,2-dichlorobenzene (50 mL) and refluxed for 48 h. After cooling, the solvent was removed in vacuo and the resulting crude oil was chromatographed on silica gel (15% ethyl acetate/hexane) to afford the title compound.

Workup

  1. temperaturerefluxed for 48 h
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo
  4. customthe resulting crude oil was chromatographed on silica gel (15% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-75de1becd53b4cb49eaa9f0c6d77c418
Source dataset
uspto-grants-2003_02
Patent number
US06515015B1

Reaction notes

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