4-Aminopyridine → HCID 22734234, compound

HRID 1057885Notes

Reaction equation

HRID 1057885 reaction equation
O[CH2:2][C:3]1[C:8]2[CH:9]([CH3:12])[CH2:10][O:11][C:7]=2[C:6]([O:13][CH3:14])=[CH:5][CH:4]=1.[NH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1>>[CH3:14][O:13][C:6]1[C:7]2[O:11][CH2:10][CH:9]([CH3:12])[C:8]=2[C:3]([CH2:2][NH:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 17274-AminopyridineHCID 22734287HCID 22734287, compound

Product 1

HCID 22734234HCID 22734234, compoundYield 26.5%

Procedure

Substantially the same procedure as in Step B of Example 48 was repeated using Compound 59a obtained in Step A of Example 59 and using 4-aminopyridine instead of 4-mercaptopyridine to give Compound 61 (26.5%) as colorless crystals.

Sources & evidence

ORD record
ord-3fb98f4d0528436396f51f02ab1a03b8
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

Loading…