Water → HCID 22734450, compound

HRID 1057908Notes

Reaction equation

HRID 1057908 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13]([C:15]2[C:24]3[O:23][CH2:22][CH2:21][O:20][C:19]=3[C:18]([O:25][CH3:26])=[CH:17][CH:16]=2)=[O:14])[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].O.O.Cl>C(O)C>[C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13]([C:15]2[C:24]3[O:23][CH2:22][CH2:21][O:20][C:19]=3[C:18]([O:25][CH3:26])=[CH:17][CH:16]=2)=[O:14])[CH:9]=[CH:10][CH:11]=1)([OH:5])=[O:3]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21885828Hydrate;hydrochlorideHCID 22734091HCID 22734091, compound

Product 1

HCID 22734450HCID 22734450, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 185 (0.19 g) obtained in Example 185 was suspended in ethanol (1 ml), mixed with a 24% aqueous sodium hydroxide solution (1.3 ml), and heat-refluxed for 2 hours. The resultant was allowed to stand for cooling, mixed with water, and adjusted to PH 2 by adding 2N hydrochloric acid water. The precipitated solid was collected by filtration to give Compound 186 (0.14 g, 80%) as colorless crystals.

Workup

  1. temperatureheat-refluxed for 2 hours
  2. temperaturefor cooling
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-fc46b7094fd949a4ae681c5c2cc8f36c
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

Loading…