HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1057927Generated: November 2, 2026
Hexamethylenetetramine → 2-Cyano-7-methoxybenzofuran-4-carbaldehyde
https://huagongshe.com/reaction/1057927
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 7-Methoxybenzofuran-2-carbonitrile | HCID 298556 | — |
| Product | 2-Cyano-7-methoxybenzofuran-4-carbaldehyde | HCID 22734299 | 21% |
Reaction Steps
A mixture of 2-cyano-7-methoxybenzofuran (4.17 g), hexamethylenetetramine (3.38 g), and trifluoroacetic acid (62 ml) was stirred at 60 to 70° C. for one hour. The mixture was concentrated and the residue was purified by silica gel column chromatography (toluene/ethyl acetate=20/1) to give Compound IIi (1.02 g, 21%) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06514996B2 |
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| Source dataset | uspto-grants-2003_02 |
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| ORD ID | ord-38e8583af9a24898924c740a5cb43c46 |
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| Source note | uspto-grants-2003_02 |
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