反应详情

温度

65 °C

A mixture of 2-cyano-7-methoxybenzofuran (4.17 g), hexamethylenetetramine (3.38 g), and trifluoroacetic acid (62 ml) was stirred at 60 to 70° C. for one hour. The mixture was concentrated and the residue was purified by silica gel column chromatography (toluene/ethyl acetate=20/1) to give Compound IIi (1.02 g, 21%) as colorless crystals.

1. concentrationThe mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (toluene/ethyl acetate=20/1)