Cyclobutylamine → HCID 18672517, compound

HRID 1057980Notes

Reaction equation

HRID 1057980 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:11][O:10]1.[CH:12]1([NH2:16])[CH2:15][CH2:14][CH2:13]1>O>[CH:12]1([NH:16][CH2:11][CH:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[Cl:1])[OH:10])[CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 75645CyclobutylamineHCID 18672511158397-38-7

Product 1

HCID 18672517HCID 18672517, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

To 2,3-dichlorophenyloxirane prepared in step 1 (assumed 0.3 mmol) was added cyclobutylamine (5.86 mmol, 0.5 ml). The solution was heated at 60° C. in a capped test tube overnight. The solution was diluted with water (1 ml), extracted with ethyl acetate (1 ml) and washed with water (2×1 ml). The solution was concentrated by vacuum centrifuge overnight to give 2-cyclobutylamino-1-(2,3-dichlorophenyl)ethanol and used without further purification.

Workup

  1. extractionextracted with ethyl acetate (1 ml)
  2. washwashed with water (2×1 ml)
  3. concentrationThe solution was concentrated by vacuum centrifuge overnight

Sources & evidence

ORD record
ord-f4f0bffe820d4a98998c385f742626c8
Source dataset
uspto-grants-2003_02
Patent number
US06515023B2

Reaction notes

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