反应详情

温度

70 °C

A suspension of Intermediate 84 (235 mg), 4-methoxybenzylamine (110 μl), tris(dibenzylideneacetone)dipalladium(0) (30.4 mg), 2-(di-tert-butylphosphino)biphenyl (41.0 mg) and sodium tert-butoxide (93.6 mg) in toluene (4.5 ml) was stirred at 70° C. for 1 hour. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain the title compound (270 mg).

1. filtrationThe reaction mixture was filtered through a Celite layer
2. customthe solvent was evaporated under reduced pressure
3. customThen, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)