HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Rosiglitazone Maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Rosiglitazone | HCID 77999 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Product | Rosiglitazone Maleate | HCID 5281055 | — |
| Product | maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate | HCID 131723756 | — |
Reaction Steps
In the final step of salt formation, rosiglitazone (V) and maleic acid were refluxed in acetone at 50° to 55° C. to obtain the maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate (1), namely rosiglitazone maleate in high yield of 90 to 95% with high grade purity and low moisture content to be effectively dry and free flowing so that it can easily be converted into a pharmaceutical composition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515132B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-4dc8adbb61bd4210a1a090bb75ed5a70 |
| Source note | uspto-grants-2003_02 |