反应详情

800 g of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (V) and 280 mg maleic acid were dissolved in 1.3 l of acetone in 5 l three necked round bottom flask. The reaction mixture was heated to 50°-55° C. and the solution was filtered and slowly cooled to obtain 986 g of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate (1) (yield 95%; mp 120-122° C.).

1. temperatureThe reaction mixture was heated to 50°-55° C.
2. filtrationthe solution was filtered
3. temperatureslowly cooled