HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Rosiglitazone | HCID 77999 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Product | maleate salt 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate | HCID 131723756 | 138,656.703% |
Reaction Steps
800 g of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (V) and 280 mg maleic acid were dissolved in 1.3 l of acetone in 5 l three necked round bottom flask. The reaction mixture was heated to 50°-55° C. and the solution was filtered and slowly cooled to obtain 986 g of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate (1) (yield 95%; mp 120-122° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515132B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-2dea0873f0c54247a9f0931fbd7aa41f |
| Source note | uspto-grants-2003_02 |