Potassium Carbonate → HCID 178505549, compound

HRID 1058099Notes

Reaction equation

HRID 1058099 reaction equation
C([O-])([O-])=O.[K+].[K+].[F:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[NH:13])=[CH:10][CH:9]=1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)=O>C(Cl)(Cl)Cl>[F:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]2[NH:14][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[N:13]=2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromideHCID 42952384-Fluorobenzamidine

Product 1

HCID 178505549HCID 178505549, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a two-phase mixture of 30% K2CO3 solution (5 ml) and chloroform (5 mL) containing 276 mg of 4-fluorobenzamidine was added a solution of 468 mg of 2-bromo-4′-chloroacetophenone in chloroform (3 mL). After stirring for 1 hr, the reaction mixture was filtered. The white crystallinesolid was washed with distilled water and dried in a vacuum oven overnight to afford 2-(4-fluorophenyl)4-(4-chlorophenyl)imidazole (Compound 1).

Workup

  1. filtrationthe reaction mixture was filtered
  2. washThe white crystallinesolid was washed with distilled water
  3. customdried in a vacuum oven overnight

Sources & evidence

ORD record
ord-95830806431743d0a9e059227e35a0a9
Source dataset
uspto-grants-2003_02
Patent number
US06515133B1

Reaction notes

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