3-Phenylprop-2-Enal → HCID 18672287, compound

HRID 1058324Notes

Reaction equation

HRID 1058324 reaction equation
[CH:1](=O)[CH:2]=[CH:3][C:4]1C=CC=C[CH:5]=1.[C:11]([C:16]1([C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:20]([CH3:22])(C)[CH2:19][CH2:18][NH:17]1)([O:13][CH2:14][CH3:15])=[O:12]>>[CH2:26]([O:25][C:23]([C:16]1([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:20]([C:22]2[CH:5]=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH2:19][CH2:18][NH:17]1)=[O:24])[CH3:27]

Participants

3

Reactant 2

HCID 3073-Phenylprop-2-EnalHCID 21866189Diethyl 3,3-dimethylpyrrolidine-2,2-dicarboxylate

Product 1

HCID 18672287HCID 18672287, compound

Procedure

Diethyl-3-phenylpyrrolidine-2,2-dicarboxylate was prepared from cinnamaldehyde (1.22 mL, 9.70 mmol) essentially according to the procedure described in U.S. Pat. No. 4,060,603 for the preparation of 2,2-dicarboethoxy-3,3-dimethyl-pyrrolidine. The resulting yellow oil was used in the next step without purification. LCMS RT=1.26 min. LCMS (M+H)=292.1.

Workup

  1. customThe resulting yellow oil was used in the next step without purification

Sources & evidence

ORD record
ord-a1c9227759bf4afdbcc940b2717876f0
Source dataset
uspto-grants-2003_02
Patent number
US06515011B2

Reaction notes

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