反应详情

温度

2.5 °C

To a solution of 97.0 g (0.646 mol) o-tolylacetic acid in 1.75 L carbon tetrachloride was added 115.0 g (0.646 mol) N-bromosuccinimide and 3.4 g (0.021 mol) 2,2′-azobisisobutyronitrile. The mixture was heated at reflux under a nitrogen atmosphere for 4 h. After the mixture was cooled to 0-5° C. for 30 min, the solids were removed by filtration and washed with a small portion of carbon tetrachloride. This solid was triturated with water (0.8 L), collected on a filter, and washed with 500 mL of water to give 2-bromomethylphenylacetic acid. The filtrate was concentrated to a volume of 150 ml, and the resulting slurry cooled to 0-5° C. for 30 min. A second batch of product was obtained.

1. temperatureThe mixture was heated
2. temperatureat reflux under a nitrogen atmosphere for 4 h
3. customthe solids were removed by filtration
4. washwashed with a small portion of carbon tetrachloride
5. customThis solid was triturated with water (0.8 L)
6. customcollected on a filter
7. washwashed with 500 mL of water