HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → D-Phenylalanyl-N-[2-(ammoniomethyl)-5-chlorobenzyl]-L-prolinamide bis(hydrochloride)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(tert-Butoxyacetyl)-D-phenylalanyl-N-(2-{[(tert-butoxycarbonyl)amino]methyl}-5-chlorobenzyl)-L-prolinamide | HCID 69939891 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | D-Phenylalanyl-N-[2-(ammoniomethyl)-5-chlorobenzyl]-L-prolinamide bis(hydrochloride) | HCID 86585777 | — |
Reaction Steps
HCl gas was bubbled through a 0° C. solution of N-(tert-Butoxyacetyl)-D-phenylalanyl-N-(2-{[(tert-butoxycarbonyl)amino]methyl}-5-chlorobenzyl)-L-prolinamide (0.073 mmol, 45 mg) in 0.500 mL ethylacetate for 2 min. Let stir 1 h and concentrated in vaccuo to give D-Phenylalanyl-N-[2-(ammoniomethyl)-5-chlorobenzyl]-L-prolinamide bis(hydrochloride). Mass Spec ES (M+1)=415.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515011B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-307af15d8d82443aaa1a73556b37c987 |
| Source note | uspto-grants-2003_02 |