HRID1058339

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OCC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CNC(=O)OC(C)(C)C

HCID69939891

N-(tert-Butoxyacetyl)-D-phenylalanyl-N-(2-{[(tert-butoxycarbonyl)amino]methyl}-5-chlorobenzyl)-L-prolinamide

C33H45ClN4O6

PRODUCTS

生成物

结构：Cl.Cl.N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1C[NH3+]

HCID86585777

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

HCl gas was bubbled through a 0° C. solution of N-(tert-Butoxyacetyl)-D-phenylalanyl-N-(2-{[(tert-butoxycarbonyl)amino]methyl}-5-chlorobenzyl)-L-prolinamide (0.073 mmol, 45 mg) in 0.500 mL ethylacetate for 2 min. Let stir 1 h and concentrated in vaccuo to give D-Phenylalanyl-N-[2-(ammoniomethyl)-5-chlorobenzyl]-L-prolinamide bis(hydrochloride). Mass Spec ES (M+1)=415.1.

WORKUP

后处理

concentrationconcentrated in vaccuo