Sodium Hydroxide → Sertraline

HRID 1058530Notes

Reaction equation

HRID 1058530 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.Cl.[OH-].[Na+]>O>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 63009Sertraline Hydrochloride

Product 1

HCID 68617SertralineYield 98%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sertraline hydrochloride (5 grams) was dissolved in water (one liter). To this solution the required amount of 1N NaOH was added until the pH of the solution was adjusted to 8.0. The resulting solids were filtered and washed with deionized water (50 mL per gram of solid). The solids were dried at 40° C. in a vacuum oven for 48 hours. The yield was 98%. mp 67° C.

Workup

  1. filtrationThe resulting solids were filtered
  2. washwashed with deionized water (50 mL per gram of solid)
  3. customThe solids were dried at 40° C. in a vacuum oven for 48 hours

Sources & evidence

ORD record
ord-2da38708d6f142e993dbf20e114f7f78
Source dataset
uspto-grants-2003_02
Patent number
US06517866B1

Reaction notes

Loading…