反应详情

Sodium hydride (0.15 g, 3 mmol) (50% in oil) was added to a stirred solution of 2,6-dimethylbenzylalcohol in acetonitril (10 ml). 8-chloro-2,3-dimethylimidazo[1,2-a]pyrazine (0.4 g, 3 mmol) was added and the reaction mixture was refluxed for 20 h. The solvent was evaporated under reduced pressure and the residue was solved in methylene chloride and washed with water. The organic layer was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using ethylacetate:petroleum ether(40-60) 1:1 as eluent. Crystallization from petroleum ether gave 0.42 g (50%) of the title compound.

1. temperaturethe reaction mixture was refluxed for 20 h
2. customThe solvent was evaporated under reduced pressure
3. washwashed with water
4. customThe organic layer was evaporated under reduced pressure
5. customthe residue was purified by column chromatography on silica gel
6. customCrystallization from petroleum ether