HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 3-(4-Methylpiperazin-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 3-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester | HCID 54333530 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 3-(4-Methylpiperazin-1-yl)benzoic acid | HCID 4741681 | — |
Reaction Steps
3-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester (4.1 g, 14.9 mmol) was dissolved in TFA: CH2Cl2 (70 ml, 1:1) and the reaction was stirred for 2 h at RT. The reaction mixture was diluted with toluene (100 ml), then was concentrated in vacuo and was used in the next reaction without further purification: MS (ES+) 221.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518267B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-d3109afe8a8a4b86b0ce03a452ab6b4a |
| Source note | uspto-grants-2003_02 |