Dichloromethane → 3-(4-Methylpiperazin-1-yl)benzoic acid

HRID 1058581Notes

Reaction equation

HRID 1058581 reaction equation
C([O:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)[CH:8]=1)(C)(C)C.C(Cl)Cl>C(O)(C(F)(F)F)=O.C1(C)C=CC=CC=1>[CH3:19][N:16]1[CH2:15][CH2:14][N:13]([C:9]2[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=2)[C:6]([OH:20])=[O:5])[CH2:18][CH2:17]1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 543335303-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester

Product 1

HCID 47416813-(4-Methylpiperazin-1-yl)benzoic acid

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

3-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester (4.1 g, 14.9 mmol) was dissolved in TFA: CH2Cl2 (70 ml, 1:1) and the reaction was stirred for 2 h at RT. The reaction mixture was diluted with toluene (100 ml), then was concentrated in vacuo and was used in the next reaction without further purification: MS (ES+) 221.3 (M+H+).

Workup

  1. concentrationwas concentrated in vacuo
  2. customwas used in the next reaction without further purification

Sources & evidence

ORD record
ord-d3109afe8a8a4b86b0ce03a452ab6b4a
Source dataset
uspto-grants-2003_02
Patent number
US06518267B1

Reaction notes

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