HCID 18668743, compound → 2-(AMINOETHYL)-1-N-BOC-PIPERIDINE

HRID 1058614Notes

Reaction equation

HRID 1058614 reaction equation
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[N+]=[N-]>[Pd].CO>[NH2:1][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]

Participants

4

Reactant 1

HCID 18668743HCID 18668743, compound

Product 1

HCID 27564212-(AMINOETHYL)-1-N-BOC-PIPERIDINEYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 43.0 g of tert-butyl 2-(2-azidoethyl)-1-piperidinecarboxylate and 2.15 g of 5% palladium on carbon in 215 ml of methanol was catalytically hydrogenated at room temperature for 9 hours. After the reaction, the catalyst was filtered off, and the filtrate was concentrated to give 37.2 g of a colorless liquid.

Workup

  1. customAfter the reaction
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-59645c1470d349f0be47b9938faadc12
Source dataset
uspto-grants-2003_02
Patent number
US06518265B1

Reaction notes

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