反应详情

温度

25 °C

A 2.5 mol/L sodium hydroxide aqueous solution (1.7 mL, 4.4 mmol) and tetrabutylammonium bromide (0.017 g, 0.051 mmol) were added to 2-chlorobenzenethiol (0.17 g, 1.0 mmol), followed by stirring at 25° C. for 10 minutes. To the reaction liquid was added a toluene (1.7 mL) solution of 2-fluoro-5-nitrobenzaldehyde (0.18 g, 1.0 mmol), followed by stirring at 110° C. for 2 hours. After the conventional post-reaction treatment, the residue was purified by silica gel chromatography (eluted by chloroform) to give 2-[(2-chlorophenyl)thio]-5-nitrobenzaldehyde (0.25 g, 83%).

1. customTo the reaction liquid
2. stirringby stirring at 110° C. for 2 hours
3. customAfter the conventional post-reaction treatment, the residue was purified by silica gel chromatography (eluted by chloroform)