HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → 2-Phenylthio-3-(2,4-dioxothiazolidin-5-ylidene-methyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | 1-Ethoxyethanol | HCID 10129898 | — |
| Reactant | 2-Chloro-3-(2,4-dioxothiazolidin-5-ylidene-methyl)quinoline | HCID 73455763 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Phenylthio-3-(2,4-dioxothiazolidin-5-ylidene-methyl)quinoline | HCID 72497702 | 36% |
Reaction Steps
2-Chloro-3-(2,4-dioxothiazolidin-5-ylidene-methyl)quinoline and thiophenol (1.2 eq) were mixed with ethoxyethanol and heated to reflux under N2 for 2 hours. The reaction mixture was allowed to cool to RT, ether was added and bright-yellow precipitate was filtered off, washed several times with ether, air dried for 24 hrs at RT to give pure product (Yield-36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518268B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-2c4466619bd043c9abcd4df045e929de |
| Source note | uspto-grants-2003_02 |