反应详情

温度

35 °C

To a solution of 2-(2-naphthyloxy)ethyl 4-bromobenzenesulfonate (Preparation 10, 380 mg, 0.93 mmol) in acetone (5 mL) at room temperature was added sodium iodide (1.0 g, 6.66 mmol). The mixture was heated at 35° C. for 16 hours and then cooled. The residual precipitate was removed by filtration and the filtrate was concentrated in vacuo. The residue was partitioned between diethyl ether (20 mL) and water (20 mL). The two layers were separated and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give the title compound (200 mg, 72%) as a pale yellow oil.

1. temperaturecooled
2. customThe residual precipitate was removed by filtration
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was partitioned between diethyl ether (20 mL) and water (20 mL)
5. customThe two layers were separated
6. dry with materialthe organic layer was dried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo