Hydrogen Bromide → HCID 178419704, compound

HRID 1058757Notes

Reaction equation

HRID 1058757 reaction equation
C1(C([NH:14][CH:15]([PH:23](=[O:25])[OH:24])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)C2C=CC=CC=2)C=CC=CC=1.[BrH:26]>>[BrH:26].[NH2:14][CH:15]([PH:23](=[O:24])[OH:25])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 178527052HCID 178527052, compound

Product 1

HCID 178419704HCID 178419704, compoundYield 87.9%

Procedure

A mixture of 14.6 g (41.6 mmol) of [1-[(diphenylmethyl)amino]-2-phenylethyl]phosphinic acid and 94 ml of aqueous 48% hydrobromic acid is refluxed for 2 hours. Two phases appear. The mixture is brought to dryness by evaporation under vacuum and under warm conditions and is then taken up in 94 ml of water. The aqueous phase is washed three times with diethyl ether. The aqueous phase, again evaporated, gives (1-amino-2-phenylethyl)phosphinic acid hydrobromide, which is taken up in 58 ml of absolute ethanol. 20.4 ml of propylene oxide are added dropwise, with stirring, at 0° C. The formation of an abundant white precipitate is observed, which is filtered off and washed with diethyl ether. 6.77 g of product are recovered (yield=87.9%).

Workup

  1. temperatureis refluxed for 2 hours
  2. customThe mixture is brought to dryness by evaporation under vacuum and under warm conditions
  3. washThe aqueous phase is washed three times with diethyl ether
  4. customThe aqueous phase, again evaporated

Sources & evidence

ORD record
ord-d4968668cc974f3fbbe46a3a2c475269
Source dataset
uspto-grants-2003_02
Patent number
US06518260B1

Reaction notes

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