反应详情

To a solution of 1 g (2.02 mmol) of methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl)amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate in 20 ml of methanol are added 20 ml of 1N sodium hydroxide. After stirring for 10 hours, the medium is acidified with 2N hydrochloric acid, the methanol is then evaporated off and the residue is extracted three times with ethyl acetate. The combined organic phases are washed with water, dried over sodium sulphate and evaporated. 0.97 g of product is recovered (yield=100%).

1. customthe methanol is then evaporated off
2. extractionthe residue is extracted three times with ethyl acetate
3. washThe combined organic phases are washed with water
4. dry with materialdried over sodium sulphate
5. customevaporated
6. custom0.97 g of product is recovered (yield=100%)