Trifluoroacetic acid methylene chloride → HCID 23562520, compound

HRID 1058774Notes

Reaction equation

HRID 1058774 reaction equation
[OH:1][P:2]([CH2:20][CH:21]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:22]([NH:24][C@H:25]([C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:23])([CH:4]([NH:12]C(OC(C)(C)C)=O)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].[F:50][C:51]([F:56])([F:55])[C:52]([OH:54])=[O:53].ClCCl>>[F:50][C:51]([F:56])([F:55])[C:52]([OH:54])=[O:53].[NH2:12][CH:4]([P:2]([CH2:20][CH:21]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:22]([NH:24][C@H:25]([C:33]([O:35][CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:23])([OH:3])=[O:1])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 69939850HCID 69939850, compound

Product 1

HCID 23562520HCID 23562520, compoundYield 98%

Procedure

Phenylmethyl N- [2 -[[hydroxy [2 -phenyl-1-[[(tert-butoxy) carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-phenylalaninate is treated with a trifluoroacetic acid/dichloromethane mixture for one hour at room temperature. The mixture is evaporated to dryness. The product obtained is precipitated from ether. The product is recovered in a yield of 98%.

Workup

  1. customThe mixture is evaporated to dryness
  2. customThe product obtained
  3. customis precipitated from ether
  4. customThe product is recovered in a yield of 98%

Sources & evidence

ORD record
ord-57b8ca1e6198435da6db2a7cee8d8b92
Source dataset
uspto-grants-2003_02
Patent number
US06518260B1

Reaction notes

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