HCID 69940123, compound → HCID 23562522, compound

HRID 1058776Notes

Reaction equation

HRID 1058776 reaction equation
[C:1]1([CH2:7][CH:8]([P:17]([CH2:27][CH:28]([CH2:50][C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)[C:29]([NH:31][C@H:32]([C:40]([O:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[O:41])[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:30])([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:18])[NH:9][C:10]([O:12]C(C)(C)C)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)=O>[CH:10]([OH:12])=[O:11].[NH2:9][CH:8]([P:17]([CH2:27][CH:28]([CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:29]([NH:31][C@H:32]([C:40]([O:42][CH2:43][C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)=[O:41])[CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[O:30])([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 69940123HCID 69940123, compound

Product 1

HCID 23562522HCID 23562522, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Phenylmethyl N-[2-[[[2-phenyl-1-[[(tert-butoxy)carbonyl]amino]ethyl]phenylmethoxyphosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-phenylalaninate is stirred for 2 hours in the presence of formic acid. The mixture is evaporated to dryness. The product is precipitated using diethyl ether. The product is recovered in a yield of 97%.

Workup

  1. customThe mixture is evaporated to dryness
  2. customThe product is precipitated
  3. customThe product is recovered in a yield of 97%

Sources & evidence

ORD record
ord-93fd57dfb87847df83ab7482f5382d76
Source dataset
uspto-grants-2003_02
Patent number
US06518260B1

Reaction notes

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