Sodium methanesulfinate → HCID 69635712, compound

HRID 1058840Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](CS(C)(=O)=O)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:25](OC(N1CCN(C2C=CC=C(CCl)C=2)CC1)=O)(C)(C)C.[CH3:46][S:47]([O-:49])=[O:48].[Na+]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:47]([CH3:46])(=[O:49])=[O:48])[C:15]=2[CH3:25])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 3

HCID 2733271Sodium methanesulfinate

HCID 69635702HCID 69635702, compound

HCID 69635711HCID 69635711, compound

Product 1

HCID 69635712HCID 69635712, compound

Procedure

4-(3-Methanesulfonylmethylphenyl)piperazine-1-carboxylic acid tert-butyl ester may be prepared in the following manner: on carrying out the operation according to the procedure of Example 10 starting with 1.55 g of 4-(3-chloromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester and 0.766 g of sodium methanesulfinate, 0.9 g of 4-(3-methanesulfonyl-methylphenyl)piperazine-1-carboxylic acid tert-butyl ester is obtained in the form of a beige powder.

Sources & evidence

ORD record: ord-11241b45a8a74949ac8b88812ece6d48
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518264B2

Reaction notes

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