Sarcosine → HCID 18669451, compound

HRID 1058935Notes

Reaction equation

HRID 1058935 reaction equation
[OH-].[Na+].[NH:3]([CH2:5][C:6]([OH:8])=[O:7])[CH3:4].[CH:9]([N:12]=[C:13]=[O:14])([CH3:11])[CH3:10]>O>[CH:9]([NH:12][C:13](=[O:14])[N:3]([CH2:5][C:6]([OH:8])=[O:7])[CH3:4])([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 1088SarcosineHCID 14798Sodium HydroxideHCID 61277Isopropyl isocyanate

Product 1

HCID 18669451HCID 18669451, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 4 g of sodium hydroxide in 75 ml of water was added 10 g of sarcosine portionwise. The solution was cooled and treated with 11.5 ml of isopropyl isocyanate. After 2 h, the reaction mixture was washed with diethyl ether and the aqueous phase acidified with concentrated HCl to <pH 2. The product was extracted twice with ethyl acetate to give 10.45 g of a white solid which was taken on to the next step.

Workup

  1. temperatureThe solution was cooled
  2. washthe reaction mixture was washed with diethyl ether
  3. extractionThe product was extracted twice with ethyl acetate

Sources & evidence

ORD record
ord-9583b8d210d0499b85a0caf2d1d3abb8
Source dataset
uspto-grants-2003_02
Patent number
US06518293B2

Reaction notes

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