反应详情

温度

80 °C

A solution of 2-bromo-1-methoxy4-(trifluoromethoxy)benzene (Description 16, 3 g, 11 mmol), 1,1-dimethylethyl 1-piperazinecarboxylate (2.47 g) and sodium tert-butoxide (1.49 g) in toluene (100 mL) was degassed with bubbling argon. (RS)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (56 mg) and tris(dibenzylideneacetone)dipalladium (0) (13.8 mg) were added and the mixture was degassed and stirred at 80° C. for 72 h. The mixture was cooled, diluted with ether (150 mL) and filtered through celite. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel, eluting with hexane/EtOAc (95:5 increasing to 85:15), to give the title compound (3.4 g, 82%). 1H NMR (250 MHz, CDCl3) δ1.48 (9H, s), 2.98-3.01 (4H, m), 3.58-3.61 (4H, m), 3.87 (3H, s), and 6.74-6.85 (3H, m). m/z (ES+) 377 (M+1).

1. customthe mixture was degassed
2. temperatureThe mixture was cooled
3. additiondiluted with ether (150 mL)
4. filtrationfiltered through celite
5. customThe solvent was evaporated under reduced pressure
6. customthe residue was purified by flash column chromatography on silica gel
7. washeluting with hexane/EtOAc (95:5 increasing to 85:15)