HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 4-acetamidopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Aminopyrimidine | HCID 68958 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-acetamidopyrimidine | HCID 316978 | — |
Reaction Steps
The 4-aminopyrimidine (1.0 equiv.) was dissolved in THF and acetic anhydride (5 equiv.) and triethylamine (1.5 equiv.) were added and the mixture was stirred at room temperature. The volatiles were removed in vacuo and the residue purified by preparative silica gel TLC to give the 4-acetamidopyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518424B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-7661aea9f78a4d83b3020d05ccdab4cd |
| Source note | uspto-grants-2003_02 |