Acetic Anhydride → 4-acetamidopyrimidine

HRID 1059066Notes

Reaction equation

HRID 1059066 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1.[C:8](OC(=O)C)(=[O:10])[CH3:9].C(N(CC)CC)C>C1COCC1>[C:8]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1)(=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 689584-Aminopyrimidine

Product 1

HCID 3169784-acetamidopyrimidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 4-aminopyrimidine (1.0 equiv.) was dissolved in THF and acetic anhydride (5 equiv.) and triethylamine (1.5 equiv.) were added and the mixture was stirred at room temperature. The volatiles were removed in vacuo and the residue purified by preparative silica gel TLC to give the 4-acetamidopyrimidine.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue purified by preparative silica gel TLC

Sources & evidence

ORD record
ord-7661aea9f78a4d83b3020d05ccdab4cd
Source dataset
uspto-grants-2003_02
Patent number
US06518424B1

Reaction notes

Loading…