HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059085Generated: October 25, 2026
Sodium Hydroxide → N-(2-chloro-5-thiazolylmethyl)-N'-methyl-N"-nitroguanidine
https://huagongshe.com/reaction/1059085
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | n-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide | HCID 107646 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | N-(2-chloro-5-thiazolylmethyl)-N'-methyl-N"-nitroguanidine | HCID 135779804 | — |
Reaction Steps
A mixture of 5.0 g of 5-(2-chlorothiazol-5-ylmethyl)-3-methyl4-nitroimino-perhydro-1,3,5-oxadiazine and 20 ml of concentrated hydrochloric acid is stirred for 2 hours at 80° C. The reaction mixture is cooled to 5° C., adjusted to a pH of about 5 with concentrated caustic soda solution and filtered. The filtering residue is mixed with diethyl ether/ethyl acetate 1:1 (v:v) and filtered again. The title compound is thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06518433B1 |
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| Source dataset | uspto-grants-2003_02 |
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| ORD ID | ord-6033ebe4bb674791a690f17c331cc132 |
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| Source note | uspto-grants-2003_02 |
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