反应详情

温度

80 °C

A mixture of 5.0 g of 5-(2-chlorothiazol-5-ylmethyl)-3-methyl4-nitroimino-perhydro-1,3,5-oxadiazine and 20 ml of concentrated hydrochloric acid is stirred for 2 hours at 80° C. The reaction mixture is cooled to 5° C., adjusted to a pH of about 5 with concentrated caustic soda solution and filtered. The filtering residue is mixed with diethyl ether/ethyl acetate 1:1 (v:v) and filtered again. The title compound is thus obtained.

1. temperatureThe reaction mixture is cooled to 5° C.
2. filtrationfiltered
3. additionThe filtering residue is mixed with diethyl ether/ethyl acetate 1:1 (v:v)
4. filtrationfiltered again