Methylamine → HCID 2452159, compound

HRID 1059129Notes

Reaction equation

HRID 1059129 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:13])[CH2:11]Cl.[CH3:14][NH2:15]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:13])[CH2:11][NH:15][CH3:14]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 707982-Chloro-N-(2,6-dimethylphenyl)acetamide

Product 1

HCID 2452159HCID 2452159, compound

Conditions

Temperature
80 °C

Procedure

A closed stainless-steel reactor is charged with 80 g of N-(2,6-dimethylphenyl)-2-chloro-acetamide and 600 ml of a 40% aqueous methylamine solution. The mixture is heated with stirring at 80° C. for 4 h and then concentrated under vacuum. The crude product is taken up in water and washed with dichloromethane. The aqueous solution is basified using sodium hydroxide solution and extracted with dichloromethane. The organic, phase is dried over sodium sulphate and concentrated to give 60 g of a colourless oil.

Workup

  1. temperatureThe mixture is heated
  2. concentrationconcentrated under vacuum
  3. washwashed with dichloromethane
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic, phase is dried over sodium sulphate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-5abd4f49235c445ea1e4ddf4dee60ee4
Source dataset
uspto-grants-2003_02
Patent number
US06518458B1

Reaction notes

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