2-Methylphenyl boronic acid → 2-methyl-1-(2'-methyl[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-propanol

HRID 1059149Notes

Reaction equation

HRID 1059149 reaction equation
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1B(O)O.Br[C:12]1[CH:13]=[C:14]([C:18]([C:23]2[N:24]=[CH:25][N:26]([C:28]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:27]=2)([OH:22])[CH:19]([CH3:21])[CH3:20])[CH:15]=[CH:16][CH:17]=1>>[CH3:20][CH:19]([CH3:21])[C:18]([C:14]1[CH:13]=[C:12]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:10])[CH:17]=[CH:16][CH:15]=1)([C:23]1[N:24]=[CH:25][N:26]([C:28]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=1)[OH:22]

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 186685221-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Product 1

HCID 186685882-methyl-1-(2'-methyl[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-propanolYield 59.2%

Procedure

By the reaction in the same manner as in Example 1-(i) using o-tolylboronic acid (0.69 g) and 1-(3-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.01 g), the amorphous title compound (0.61 g) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-66a90cf4a11f4014b6aa0b1ce44b56ab
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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