HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 18668569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,4-Difluorophenylboronic acid | HCID 2734334 | — |
| Reactant | 1-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol | HCID 18668522 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 18668569 | HCID 18668569 | 100.3% |
Reaction Steps
By the reaction in the same manner as in Example 4-(ii) using 1-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (6.00 g), 2,4-difluorophenylboronic acid (2.82 g), 2M aqueous sodium carbonate solution (45 ml) and tetrakis(triphenylphosphine)palladium(0) (647 mg), the yellow amorphous title compound (6.39 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-d0123ba6880d4023aa7401ee9ea7c695 |
| Source note | uspto-grants-2003_02 |