Pyridinium chloride → 1-(2',4'-difluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol

HRID 1059152Notes

Reaction equation

HRID 1059152 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([C:20]2[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=2)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:10]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:10]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668569HCID 18668569, compound

Product 1

HCID 1784501311-(2',4'-difluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanolYield 80.7%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-(2′,4′-difluoro[1,1′-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (6.31 g) and pyridine hydrochloride (2.17 g), the title compound (2.93 g) was obtained as colorless needle crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-e1de560affc4485894f2d0f9775fbc33
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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