HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 1-(2',4'-difluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | HCID 18668569 | HCID 18668569 | — |
| Product | 1-(2',4'-difluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | HCID 178450131 | 80.7% |
Reaction Steps
By the reaction in the same manner as in Example 4-(iii) using 1-(2′,4′-difluoro[1,1′-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (6.31 g) and pyridine hydrochloride (2.17 g), the title compound (2.93 g) was obtained as colorless needle crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518257B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-e1de560affc4485894f2d0f9775fbc33 |
| Source note | uspto-grants-2003_02 |