Pyridinium chloride → HCID 178466228, compound

HRID 1059165Notes

Reaction equation

HRID 1059165 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:17]3[N:18]=[CH:19][N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:21]=3)([OH:16])[CH3:15])[CH:9]=2)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([C:17]3[N:18]=[CH:19][NH:20][CH:21]=3)([OH:16])[CH3:15])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 186685141-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-ethanol

Product 1

HCID 178466228HCID 178466228, compoundYield 68.8%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 1-(4′-fluoro[1,1′-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-ethanol (1.51 g) and pyridine hydrochloride (599 mg), the title compound (559 mg) was obtained as colorless plate crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-5c0221903f5b4fa6bb8a811e176e7ff7
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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