Pyridinium chloride → 1-(1H-imidazol-4-yl)-2-methyl-1-[3-(2-thienyl)phenyl]-1-propanol

HRID 1059167Notes

Reaction equation

HRID 1059167 reaction equation
[CH3:1][CH:2]([CH3:40])[C:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[S:36][CH:37]=[CH:38][CH:39]=2)[CH:30]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[OH:4].Cl.N1C=CC=CC=1>>[NH:8]1[CH:9]=[C:5]([C:3]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]3[S:36][CH:37]=[CH:38][CH:39]=3)[CH:30]=2)([OH:4])[CH:2]([CH3:1])[CH3:40])[N:6]=[CH:7]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668565HCID 18668565, compound

Product 1

HCID 1784501351-(1H-imidazol-4-yl)-2-methyl-1-[3-(2-thienyl)phenyl]-1-propanolYield 87.6%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-methyl-1-[3-(2-thienyl)phenyl]-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.21 g) and pyridine hydrochloride (465 mg), the title compound (585 mg) was obtained as colorless plate crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-beca95f8ccd24fb5961d6d87d87c2ce9
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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