Hydrochloric Acid → HCID 178458226, compound

HRID 1059192Notes

Reaction equation

HRID 1059192 reaction equation
[OH:1][C:2]([C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([NH:41][C:42](=[O:44])[CH3:43])[CH:36]=2)=[CH:31][CH:30]=1)([C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1)[CH2:3][CH3:4].Cl>[C].[Pd]>[OH:1][C:2]([C:29]1[CH:30]=[CH:31][C:32]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([NH:41][C:42](=[O:44])[CH3:43])[CH:36]=2)=[CH:33][CH:34]=1)([C:5]1[N:6]=[CH:7][NH:8][CH:9]=1)[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18668519HCID 18668519, compound

Product 1

HCID 178458226HCID 178458226, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 41-(ii) using N-[4′-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-yl]acetamide (1.31 g), 10% palladium carbon (1.31 g) and 1N hydrochloric acid (2.27 ml), the colorless amorphous title compound (640 mg) was obtained.

Sources & evidence

ORD record
ord-18a9a0513d25491296f2dee1a5143450
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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