Hydrochloric Acid → HCID 178444931, compound

HRID 1059196Notes

Reaction equation

HRID 1059196 reaction equation
[OH:1][C:2]([C:31]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([NH:43][C:44](=[O:46])[CH3:45])[CH:38]=2)=[CH:33][CH:32]=1)([C:7]1[N:8]=[CH:9][N:10](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:11]=1)[CH2:3]C(C)C.Cl>[C].[Pd]>[OH:1][C:2]([C:31]1[CH:32]=[CH:33][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([NH:43][C:44](=[O:46])[CH3:45])[CH:38]=2)=[CH:35][CH:36]=1)([C:7]1[N:8]=[CH:9][NH:10][CH:11]=1)[CH2:3][CH:2]([CH2:7][CH3:11])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18668553HCID 18668553, compound

Product 1

HCID 178444931HCID 178444931, compoundYield 34.5%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 41-(ii) using N-[4′-[1-hydroxy-3-methyl-1-(1-trityl-1H-imidazol-4-yl)butyl][1,1′-biphenyl]-3-yl]acetamide (1.31 g), 10% palladium carbon (386 mg) and 1N hydrochloric acid (0.637 ml), the colorless amorphous title compound (141 mg) was obtained.

Sources & evidence

ORD record
ord-55c839f242c94a5db3012e14e8817052
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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