Pyridinium chloride → HCID 178450098, compound

HRID 1059208Notes

Reaction equation

HRID 1059208 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([OH:47])([C:23]4[N:24]=[CH:25][N:26](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:27]=4)[CH:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=3)[CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl.N1C=CC=CC=1>>[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([OH:47])([C:23]4[N:24]=[CH:25][NH:26][CH:27]=4)[CH:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=3)[CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668572N-cyclopropyl-4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-carboxamide

Product 1

HCID 178450098HCID 178450098, compoundYield 29%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-cyclopropyl-4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-carboxamide (2.13 g) and pyridine hydrochloride (650 mg), the title compound (375 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-63961c582c084933b7e9ba461d5c02c3
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

Loading…