Hydrochloric Acid → HCID 178485318, compound

HRID 1059213Notes

Reaction equation

HRID 1059213 reaction equation
[OH:1][CH:2]([C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([NH:43][CH3:44])=[O:42])[CH:36]=2)=[CH:31][CH:30]=1)[CH2:3][CH2:4][C:5]1[N:6]=[CH:7][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1.Cl>[C].[Pd]>[OH:1][CH:2]([C:29]1[CH:30]=[CH:31][C:32]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([NH:43][CH3:44])=[O:42])[CH:36]=2)=[CH:33][CH:34]=1)[CH2:3][CH2:4][C:5]1[N:6]=[CH:7][NH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69532177HCID 69532177, compound

Product 1

HCID 178485318HCID 178485318, compoundYield 72.1%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 41-(ii) using [4′-[1-hydroxy-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl[1,1′-biphenyl]-3-carboxamide (1.29 g), 10% palladium carbon (1.29 g)and 1N hydrochloric acid (2.23 ml), the colorless amorphous title compound (540 mg) was obtained.

Sources & evidence

ORD record
ord-e3f76497e534450d88e15564278dbe56
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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