Hydrochloric Acid → HCID 178485319, compound

HRID 1059214Notes

Reaction equation

HRID 1059214 reaction equation
[OH:1][CH:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([NH:44][CH3:45])=[O:43])[CH:37]=2)=[CH:32][CH:31]=1)[CH2:3][CH:4]=[CH:5][C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1.Cl>[C].[Pd]>[OH:1][CH:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([NH:44][CH3:45])=[O:43])[CH:37]=2)=[CH:34][CH:35]=1)[CH2:3][CH2:4][CH2:5][C:6]1[N:7]=[CH:8][NH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69532123HCID 69532123, compound

Product 1

HCID 178485319HCID 178485319, compoundYield 65.8%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 41-(ii) using [4′-[1-hydroxy-(1-trityl-1H-imidazol-4-yl)-3-butenyl]-N-methyl[1,1′-biphenyl]-3-carboxamide (690 mg), 10% palladium carbon (690 mg) and 1N hydrochloric acid (1.17 ml), the colorless amorphous title compound (269 mg) was obtained. The colorless amorphous title compound (420 mg) was obtained.

Sources & evidence

ORD record
ord-edb05ec3082046438581fd0a6c3ccc26
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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